I'd really switch it up reverting to a 5 at the back. Luton are similar to Plymouth in that they play a block with 5 at the back, big physical players that will be a handful. The whole point of switching to a 4-3-3 (or variation) is to accommodate and focus on our good wing play, Sakamoto has been quiet the last few, no EMC, Wright looked better through the middle (when he gets service). So here's my bid.... Wilson in goal (protecting Collins) - back 5 to help deal with the physicality and quick counter breaks with Sakamoto more hybrid when grimes drops deep, MVE push to his more natural RB position. MVE to provide pace from balls in covering Lati. Simms and Wright feeding off each other. It will be a scrappy and very tight game, I'd be prepped for balls into the box and these two to make a nuisance. I'd be quick to replace Simms with Bassette in second half if its not working.
Wilson
Sakamoto MVE Lati Kitching Dasilva
Grimes Sheaf
Rudoni
Simms Wright