fernandopartridge
Well-Known Member
They're pretty 'armless when all is said and done
They're pretty 'armless when all is said and doneAre Thalidomide jokes frowned up now?
Fuck sake, stealing my thunderThey're pretty 'armless when all is said and done
They're pretty 'armless when all is said and done
What’s the smallest pub in the world?They're pretty 'armless when all is said and done
The Valneva vaccine in the table that @Bugsy posted earlier in the thread appears to be an inactivated live virus. I have never heard of Valneva, but it's possibly a recent merger of companies that were more widely-known (note that these mergers and name changes often happen as a result of a knock to their capital due to failure of a drug in their advanced pipeline).A question for the science bods - would this be classed as a ‘live’ vaccine? The reason I ask is that I might have mentioned my daughter is on immuno-suppressants and when we enquired about a flu vaccination for this winter, we were told she couldn’t have the ‘live’ version of it (the nasal spray) so would have to have a jab instead.
The Valneva vaccine in the table that @Bugsy posted earlier in the thread appears to be an inactivated live virus. I have never heard of Valneva, but it's possibly a recent merger of companies that were more widely-known (note that these mergers and name changes often happen as a result of a knock to their capital due to failure of a drug in their advanced pipeline).
The childhood seasonal flu vaccine given as a nasal spray is what is known as a "live attenuated virus". This is a strain of the virus which has been modified such that it is biologically incapable of causing the normal infection. However, as you know from your daughter, people who have a compromised immune system for whatever reason are still at risk of developing the disease from these attenuated strains (as they are for many bacteria and viruses that the "well" population live with quite happily all the time), so they are "contra-indicated". This is a little perverse, in my view, since someone who is immunocompromised is at higher risk from the disease too.
The adult (injected) seasonal flu vaccine is an inactivated live virus (in the same mould as the Valneva offering appears to be). This means that they take the live virus, and inactivate it by a chemical method (usually) to render it supposedly incapable of causing the disease. My beef with these is that the inactivation process is not always perfect - it is based on so-called "lab validation" tests of the method, which are certified as reducing the level of live virus by a defined number of orders of magnitude (factors of 10). Hence the Domestos claim "kills 99.99% of bacteria" - a 10,000-fold reduction or "4 log kill", as it's known.
I don't know what log kill they require to prove an inactivated live vaccine is safe to use, but i know of a number of people who have had VERY flu-like symptoms in some years, so i would prefer to put my trust in biological rather than chemical inactivation.
The two vaccines that are seemingly in the lead in the race for Covid-19 (Pfizer & AstraZeneca) are neither of these things - they are nothing more than the coronavirus coat protein ("Spike") in various forms. The Spike protein on its own cannot cause disease (as far as the overwhelming body of evidence goes). The only question i would ask from your daughter's perspective is what is the chance of the remaining parts of the Adenovirus (AstraZeneca vaccine) genome being able to cause an adenovirus (common cold) infection. I believe it would be extremely low, but i don't know the precise details of the modification that they are using. The ones which are totally "gutted" are extremely tough to grow in large quantities, so i would suggest they have gone with an E1-E3 deleted one. The other thing to note is that the Adenovirus backbone they are using is from a virus that causes disease in chimpanzees, and almost certainly can't in humans. But we may have heard about viruses jumping species already somewhere in this saga.
Sorry for the wordy response, but hope this helps - i'd be putting my daughter forward if i was in your position, as the risk from Covid-19 to her is probably quite high.
Here's me making sure it's OK to crack a joke and every other fucker jumps in and cracks them.
Political Correctness gone mad.
I'm absolutely convinced that medicines, vaccines and the like that come to market in the UK (particularly those which have been through development in the UK) are safe, and the data from Phase III clinical trials seen by the oversight body (Medicines and Healthcare Products Regulatory Authoity, MHRA) will indicate any concerns.One for the more knowledgeable on here, I'm coming up to 60, no health problems and would take the vaccine if offered, my only worry is how quick this is coming to market. I've seen several representations of how drugs are brought to market and most tend to span several years before a release to the general public, as I say my only worry is the rush on this one, happy for people in the know to put my mind at rest
I'm absolutely convinced that medicines, vaccines and the like that come to market in the UK (particularly those which have been through development in the UK) are safe, and the data from Phase III clinical trials seen by the oversight body (Medicines and Healthcare Products Regulatory Authoity, MHRA) will indicate any concerns.
But that is my personal stance, based on my background in scientific research and now in biosecurity.
I know it's slightly perverse, but I've been reassured whenever they've paused trials etc. It shows they are still following process, just turbocharged.One for the more knowledgeable on here, I'm coming up to 60, no health problems and would take the vaccine if offered, my only worry is how quick this is coming to market. I've seen several representations of how drugs are brought to market and most tend to span several years before a release to the general public, as I say my only worry is the rush on this one, happy for people in the know to put my mind at rest
I'm absolutely convinced that medicines, vaccines and the like that come to market in the UK (particularly those which have been through development in the UK) are safe, and the data from Phase III clinical trials seen by the oversight body (Medicines and Healthcare Products Regulatory Authoity, MHRA) will indicate any concerns.
But that is my personal stance, based on my background in scientific research and now in biosecurity.
What’s the smallest pub in the world?
The Thalidomide Arms.
Its ALWAYS okay to crack a joke. Ricky Gervais once said, if you think of something funny, dont waste it by not saying it!Here's me making sure it's OK to crack a joke and every other fucker jumps in and cracks them.
Political Correctness gone mad.
Whats surprising me, is the ammount of people who class themselves as the "vulnerable" category, that are petrified of this unknown virus, but would jump at the chance to have an unknown injection put directly in to their system! With no knowledge of the injection or any side effects they'll happily roll their sleeve up!One for the more knowledgeable on here, I'm coming up to 60, no health problems and would take the vaccine if offered, my only worry is how quick this is coming to market. I've seen several representations of how drugs are brought to market and most tend to span several years before a release to the general public, as I say my only worry is the rush on this one, happy for people in the know to put my mind at rest
Why has he never bothered to say anything funny then?Its ALWAYS okay to crack a joke. Ricky Gervais once said, if you think of something funny, dont waste it by not saying it!
Sent from my SM-N960F using Tapatalk
Yup.That's what the trials are for though, to test the injection and look for side effects. Nobody's having anything that isn't approved safe
But the trials will be over, in less than 6 months, what if there is a long term issue?That's what the trials are for though, to test the injection and look for side effects. Nobody's having anything that isn't approved safe
Yup.
I know that medics have pointed out the virus is REMARKABLY DANGEROUS.
I know that medics will have passed any vaccine.
We already have vaccines for TB, flu etc. Smallpox is the only disease eradicated, and that was by vaccine.
Therefore, I'll trust the people with the expertise that I don't have. There is, as always, a risk. But the risk is relatively small.
Ultimately, you have to trust people with expertise!
But the trials will be over, in less than 6 months, what if there is a long term issue?
That's what worries some buggers.
Yup.
I know that medics have pointed out the virus is REMARKABLY DANGEROUS.
I know that medics will have passed any vaccine.
We already have vaccines for TB, flu etc. Smallpox is the only disease eradicated, and that was by vaccine.
Therefore, I'll trust the people with the expertise that I don't have. There is, as always, a risk. But the risk is relatively small.
Ultimately, you have to trust people with expertise!
But the trials will be over, in less than 6 months, what if there is a long term issue?
That's what worries some buggers.
You still keep coming back hereBored of experts m8
You still keep coming back here
Life would be so much simpler.I need to see if you’d two foot the situation before I can form my own opinion.
We just need to learn how to be more streetwise.If we gave covid an early reducer and set our stall out we'd all be allowed in shoe shops by now.
How you doing stranger?I would take it. Because of my history I had to shield from March and got the letter from the Gov telling me not to go out as I'm classed as CEV. In the grand scheme of things I presume I would be behind NHS Workers and the elderly in getting it.
I get the flu jab every year too. I just think of it as something else I would need to have.
How you doing stranger?
Good to see you on here .
Get back into that music thread and give us some electronic soundtracks etc .
We use cookies and similar technologies for the following purposes:
Do you accept cookies and these technologies?
We use cookies and similar technologies for the following purposes:
Do you accept cookies and these technologies?