My understanding, from talking at length to a couple of the consultants involved in this at UHCW is that when people say it reduces your appetite they are massively over simplifying what is happening.
To be fair some of this stuff goes over the head so this is only the basics but from the parts that I can follow there's an almond shaped part of the brain involved. When they study people that really struggle to lose weight they find that this part of the brain is a different size. This is linked to signals being sent to the brain, or more accurately not being sent. In short when you eat certain reactions should be triggered by your brain and signals sent that you are now full and for some people that simply doesn't happen.
What the drug does is stimulate that response. That's why you hear people talk about 'food noise', for people like this their brain is 24/7 screaming for more food to fuel the body. People in that situation start taking the drug and talk about it like someone flipping a switch.
i think there’s a bit of confusion in this explanation...saying that essentially some people’s brains don’t know they’re full and that Ozempic fixes that oversimplifies how hunger and fullness actually work. it’s not like there’s some part of the brain that’s completely broken for people who struggle with weigh - it’s more about how the signals are processed and how hormones like GLP-1, leptin, and ghrelin function.
basically ozempic mimics a hormone your body already produces (GLP-1), which helps controle and regulate hunger and fullness. It works in the brain (in areas like the hypothalamus), not by “fixing” anything structural, but by amplifying and increasing the signals that tell you you’re full or reducing how much food you crave.
but it doesn’t just bring levels back to “normal”—it amplifies the effect to a degree that isn’t naturally achievable for most people. GLP-1 is a hormone your body releases after eating, signaling to your brain that you’re full and reducing your appetite. by copying or mimicking GLP-1, ozempic essentially supercharges this process, making you feel fuller for much longer and significantly reducing hunger cues.
this sort of superfiecial amplification is what allows people to maintain extreme calorie deficits without the usual constant hunger or cravings that would generally make it unbearable.
It also slows down how quickly your stomach empties, which makes you feel full for longer after eating. That’s why people talk about “food noise” you mentioned disappearing...ozempic helps reduce those constant hunger pangs or thoughts about food, but it’s not magic, and it doesn’t work the same for everyone
read a lot into it because an immediate family member lost a huge amount of weight on it and is now figuring out how to wean off it without piling it all on again